Endocrine Abstracts

Thyroid hormones exert their effects by stimulation of thyroid hormone receptors that have different tissue distribution and metabolic targets. TRβ is predominant in liver and mainly responsible for effects on cholesterol and lipoprotein metabolism, whereas TRα is most important in fat, muscle and heart. Thyroid hormone analogs (thyromimetics, tiromes) have been developed that activate TRβ are selectively taken up and/or activated by the liver. Such compounds st...